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Nutrition continued

Medicinal Mushrooms.

Products licence in Japan Extracts from mushrooms:

KRESTIN / PSK (oral) ‐ Digestive, Lung and Breast Cancer

LENTINAN (injection) ‐ Stomach Cancer Lentinan (from shitake mushrooms) ‐ gastrointestinal cancer

SIZOFRAN / SPG (injection) ‐ Cervical Cancer. Grifola frondosa (from mattock mushrooms) ‐ regression of lung, liver,

pancreatic and breast, reductions in side‐effects from chemotherapy

Agaricus subrufescens.

Immune changes induced by mushroom polysaccharide‐based supplementation include:

• Increased NK cell activation Change in Th1‐Th2 immune cell shift, which:

• Increased macrophage activation ‐ Lowered resistance to viral and other pathogens.

• Increased cytotoxic T‐cell activation ‐ Increases in fatigue and incidence of depression.

• Increased IFN‐γ, IL‐2 and TNF‐β production ‐ Increases incidence of allergic and auto‐immune conditions such as asthma

• Reduced IL‐4 production and SLE.

• Inhibition of prostaglandin synthesis ‐ Persistent humoral immune responses exacerbate recruitment and

activation of innate immune cells in neoplastic microenvironments where

they regulate tissue remodeling, pro‐angiogenic and pro‐survival pathways

that together potentiate cancer development.1.